Ecole Polytechnique Fédérale de Lausanne
 
EPFL is one of the two Swiss Federal Institutes of Technology and is located in Lausanne. Its major research focus is basic sciences and engineering. EPFL is ranked among the top universities in the world - placed 1st place in Europe (shared with Cambridge University) in the 2011 ARWU rankings in the field of Engineering/Technology and Computer Sciences and 20th place worldwide. The school has the stated mission to: Educate engineers and scientists; Be a national centre of excellence in science and technology; Provide a hub for interaction between the scientific community and industry. EPFL has 4300 staff members and about 9300 students. The Institute of chemical sciences and engineering (ISIC) provide an educational and research environment in chemical sciences and engineering for undergraduates, graduates and postgraduates. The chemical sciences are of vital importance in the modern world, and the research undertaken in our Institute spans fundamental studies in theoretical chemistry and biochemistry to applications in devices and engineering. Fundamental research in our Institute led to the discovery of dye sensitized solar cells and drugs and diagnostics developed within our Institute are now in widespread use. We continue to take a leading role in all aspects of chemistry including research at the interface of biology and physics as well as in sustainability and nanoscience.


Staff Expertise
  • Prof E. Dubikovskaya is Tenure Track Assistant Professor of bio-organic chemistry and molecular imaging at the Institute of chemical sciences and engineering (ISIC) http://isic.epfl.ch. The lab specializes in the development of novel imaging reagents for image-guided surgery of cancer, early diagnostics of bacterial infections, as well other probes aimed for preclinical research. It provides extensive training in organic synthetic chemistry and imaging techniques. Previously, several imaging reagents have been developed by Dubikovskaya and co-workers that have been subsequently licensed by the companies for preclinical research.

Key facilities and infrastructure
  • The Institute where the lab is located provides an educational and research environment in chemical sciences and engineering for PhD students and postdoctoral fellows.
  • The Institute is fully equipped for performing chemical synthesis of the new reagents and their validation in cells and living animals.
  • The imaging facility include a preclinical imaging system (IVIS Spactrum), various optical microscopes, several MRI systems including an ultra- high magnetic field (17.6 Tesla) instrument. Therefore, the Institute has all the necessary equipment for performance of the proposed work.

Current Involvement in Research and Training Programmes
  • 2013 FP7 Vaccines and Imaging Partnership (VIP)

Publications
  • Godinat A, et. al. ACS Chem. Biol. 2013; 8:987-989.
  • Henkin AH et al. ACS Chem. Biol. 2012; 7:1884–1891.
  • Van de Bittner, GC et al. Proc Natl Acad Sci USA 2010; 107:21316-21321.
  • Cohen AS et al . J. Am Chem Soc 2010; 132:8563-8565.
  • Dubikovskaya EA et al. Proc Natl Acad Sci USA 2008; 105:12095-12096.


Overview of all participants ...