University of Sheffield
 
The University of Sheffield is one of the top research-led Universities in the UK and a member of the UK's prestigious ‘Russell Group’ (ie. the top 20 research-intensive Universities). The 2014 Research Excellence Framework confirmed the University of Sheffield as a world-leading university with excellent research across a range of disciplines.The Medical school has a track record of discovery and innovation with five research departments, Cardiovascular Science, Human Metabolism, Infection & Immunity, Neuroscience and Oncology. The Department of Oncology has developed rapidly since the early 1990s. Over the last ten years there has been a tremendous increase in the quality and quantity of both clinical and laboratory based research. High quality, senior appointments have been made to ensure the establishment and development of an internationally competitive cancer research programme. The Department provides a dynamic, exciting research environment with an internationally important portfolio of basic, clinical and translational cancer research with scientists that are engaged at the cutting-edge of oncology research. Within the department the Academic Unit of Inflammation and Tumour Targeting focuses on the role of macrophages in tumour progression, anti-cancer gene therapy and response of tumours to conventional therapies; Development of anti-vascular and angiogenic agents; Mathematical modelling of tumour inflammation and angiogenesis.



Staff Expertise
  • Prof. Lewis’s lab in the Medical School is one of the leading tumour macrophage research groups in the world. She has published extensively in this area and offers training and supervision for PhD students and/or early-stage researchers on the project in this. She will supervise the staff working on the phenotyping and/or targeting of macrophages in this project.
  • Dr Russell Hughes is a senior postdoc in the group of Prof. Lewis. Dr Russell uses various molecular and cellular methods to characterise tumour associated macrophages in hypoxic areas of the tumours. He is a highly trained PhD scientist with over 10 years of experience in tumour macrophage biology
  • University Lecturer Dr Munitta Muthana focuses her research in the role of innate immune cells like macrophages and dendritic cells in diseases including cancer and rheumatoid arthritis. Dr. Muthana has developed innovative cell-based methods to target anticancer therapy to tumors. She is a highly trained PhD scientist with over 10 years of expertise in tumour macrophage biology.

Key facilities and infrastructure
  • Prof Lewis’s lab in Sheffield is fully equipped and staffed for the study of the phenotypic analysis of mouse and human monocytes/macrophages, and their targeting in vivo by nanoparticles and various forms of therapeutic virus.
  • Her group also has access to a number of fully staffed Core Facilities in the Medical School in Sheffield (eg. Confocal microscopy, FACS, Histology, Microarrays, Genetics, etc. See: www.sheffield.ac.uk/medicine/research/corefacilities). This means that her lab is able to offer a suitable environment for supervising the research and training of the recruited, Early-Stage Researchers.

Publications
  • Muthana M et al. Cancer Res 2013; 73:490-495
  • De Palma M and Lewis CE. Nature 2011; 472: 303-304.
  • Welford AF et al. J Clin Invest 2011; 121:1969-1973.
  • Muthana M et al. Cancer res 2011; 71:1805-1815.
  • Fang H-Y et al. Blood 2009; 114:844-859.


Overview of all participants ...